基本信息

姓名：陈子江

职称：教授

职务：山东大学讲席教授

电子邮箱：chenzijiang@vip.163.com

教育经历

1984年山东医学院毕业。

1989年山东医科大学医学博士。

工作经历

1989年12月任山东医科大学临床医学部讲师。

1993年破格晋升教授，同时任山东省立医院妇科主任医师。

2001年9月任山东省立医院妇产科主任、生殖医学中心主任。

2002年2月任山东省立医院副院长。

2006年12月起先后兼任山东大学医学院副院长，生殖内分泌教育部重点实验室主任，国家辅助生殖与优生工程技术研究中心主任。

2013年5月任山东大学副校长。

2015年7月兼任山东大学齐鲁医学部部长。

研究方向

1. 生殖内分泌疾病发病机制研究。

2. 卵子发生和胚胎发育的调控研究。

3. 生殖障碍疾病RCT与队列研究。

4. 出生缺陷防控研究。

5. 生殖医学新技术研发及转化应用。

获得荣誉

曾获中国科学院院士；国家发明奖；国家科技进步奖；何梁何利科技进步奖；全国创新争先奖；谈家桢生命科学成就奖。

代表性论文

1、Xuepeng Chen^#, Yuwen Ke^#, Keliang Wu^#, Han Zhao^#, Yaoyu Sun, Lei Gao, Zhenbo Liu, Jingye Zhang, Wenrong Tao, Zhenzhen Hou, Hui Liu, Jiang Liu* & Zi-Jiang Chen*. Key role for CTCF in establishing chromatin structure in human embryos. Nature. 2019 Dec;576(7786):306-310.

2、Zhuoning Zou, Chuanxin Zhang, Qiuyan Wang , Zhenzhen Hou , Zhuqing Xiong, Feng Kong, Qiujun Wang, Jinzhu Song, Boyang Liu , Bofeng Liu , Lijuan Wang , Fangnong Lai, Qiang Fan, Wenrong Tao, Shuai Zhao, Xiaonan Ma, Miao Li, Keliang Wu, Han Zhao*, Zi-Jiang Chen*, Wei Xie*. Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation. Science. 2022 Oct 7;378(6615):abo7923.

3、Lei Gao, Keliang Wu, Zhenbo Liu, Xuelong Yao, Shenli Yuan, Wenrong Tao, Lizhi Yi, Guanling Yu, Zhenzhen Hou, Dongdong Fan, Yong Tian, Han Zhao, Jianqiao Liu*, Zi-Jiang Chen*, Jiang Liu*. Chromatin Accessibility Landscape in Human Early Embryos and its Association with Evolution. Cell. 2018 Mar 22;173(1):248-259.e15.

4、Hanni Ke, Shuyan Tang, Ting Guo, Dong Hou, Xue Jiao, Shan Li, Wei Luo, Bingying Xu, Shidou Zhao, Guangyu Li, Xiaoxi Zhang, Shuhua Xu, Lingbo Wang, Yanhua Wu, Jiucun Wang, Feng Zhang*, Yingying Qin*, Li Jin*, Zi-Jiang Chen*. Landscape of pathogenic mutations in premature ovarian insufficiency. Nature Medicine. 2023, In press. 2023 Feb 2.doi: 10.1038/s41591-022-02194-3. Online ahead of print.

5、Junhao Yan^#, Yingying Qin^#, Han Zhao^#, Yun Sun^#, Fei Gong^#, Rong Li^#, Xiaoxi Sun^#, Xiufeng Ling^#, Hong Li^#, … , Heping Zhang, Richard S Legro, Zi-Jiang Chen*. Live Birth with or without Preimplantation Genetic Testing for Aneuploidy. N Engl J Med. 2021 Nov 25;385(22):2047-2058.

6、Yuhua Shi, Yun Sun, Cuifang Hao, Heping Zhang, Daimin Wei, Yunshan Zhang, Yimin Zhu, Xiaohui Deng, Xiujuan Qi, Hong Li, Xiang Ma, Haiqin Ren, Yaqin Wang, Dan Zhang, Bo Wang, Fenghua Liu, Qiongfang Wu, Ze Wang, Haiyan Bai, Yuan Li, Yi Zhou, Mei Sun, Hong Liu, Jing Li, Lin Zhang, Xiaoli Chen, Songying Zhang, Xiaoxi Sun, Richard S. Legro, and Zi-Jiang Chen*. Frozen versus Fresh Embryo Transfer in Ovulatory Women. N Engl J Med, 2018 Jan 11; 378:126-36.

7、Yingying Qin, Feng Zhang, Zi-Jiang Chen*. BRCA2 in Ovarian Development and Function. N Engl J Med. 2019; 380:1086-1087.

8、Zi-Jiang Chen*, Yuhua Shi, Yun Sun, Bo Zhang, Xiaoyan Liang, Yunxia Cao, Jing Yang, Jiayin Liu, Daimin Wei, Ning Weng, Lifeng Tian, Cuifang Hao, Dongzi Yang, Feng Zhou, Juanzi Shi, Yongle Xu, Jing Li, Junhao Yan, Yingying Qin, Han Zhao, Heping Zhang, Richard S. Legro. Fresh versus Frozen Embryos for Infertility in Polycystic Ovary Syndrome. N Engl J Med, 2016 Aug 11; 375(6):523-33.

9、Daimin Wei, Jia-Yin Liu, Yun Sun, Yuhua Shi, Bo Zhang, Jian-Qiao Liu, Jichun Tan, Xiaoyan Liang, Yunxia Cao, Ze Wang, Yingying Qin, Han Zhao, Yi Zhou, Haiqin Ren, Guimin Hao, Xiufeng Ling, Junzhao Zhao, Yunshan Zhang, Xiujuan Qi, Lin Zhang, Xiaohui Deng, Xiaoli Chen,Yimin Zhu, Xiaohong Wang, Li-Feng Tian, Qun Lv, Xiang Ma, Heping Zhang, Richard S Legro, Zi-Jiang Chen*. Frozen versus fresh single blastocyst transfer in ovulatory women: a multicenter, randomized controlled trial. Lancet. 2019 Mar 30;393(10178):1310-1318.

10、Yongyong Shi, Han Zhao, Yuhua Shi, Yunxia Cao, Dongzi Yang, Zhiqiang Li,Bo Zhang, Xiaoyan Liang, Tao L, Jianhua Chen, Jiawei Shen, Junzhao Zhao,Li You, Xuan Gao, Dongyi Zhu, Xiaoming Zhao, Ying Yan, Yingying Qin, Wenjin Li, Junhao Yan, Qingzhong Wang, Junli Zhao, Ling Geng, Jinlong Ma, Yueran Zhao,Guang He, Aiping Zhang, Shuhua Zou, Aijun Yang, Jiayin Liu, Weidong Li, Baojie Li, Chunling Wan, Ying Qin, Juanzi Shi, Jing Yang, Hong Jiang, Jin-e Xu, Xiujuan Qi, Yun Sun,Yajie Zhang, Cuifang Hao, Xiuqing Ju, Dongni Zhao, Chun-e Ren, Xiuqing Li, Wei Zhang, Yiwen Zhang, Jiangtao Zhang, Di Wu, Changming Zhang, Lin He*, and Zi-Jiang Chen*. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nature Genetics. 2012; 44(9): 1020-5.

11、Keliang Wu, Cuiqing Zhong, Tailai Chen, Xiaoyu Zhang, Wenrong Tao, Jingye Zhang, Hongchang Li, Han Zhao*, Jinsong Li* and Zi-Jiang Chen*..Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy. Cell Research. 2017 Aug; 27(8):1069-1072.

12、Tailai Chen, Yuehong Bian, Xiaoman Liu, Shigang Zhao, Keliang Wu, Lei Yan, Mei Li, Zhenglin Yang, Hongbin Liu, Han Zhao*, Zi-Jiang Chen*. A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility. Am J Hum Genet. 2017 Sep 7; 101(3):459-465.