基本信息

姓名：孟安明

职称：教授

职务：清华大学生命科学学院教授

电子邮箱：mengam@mail.tsinghua.edu.cn

教育经历

1979-1983，西南农业大学 学士。

1987-1990，英国诺丁汉大学 博士。
工作经历

1990－1996，中国农业大学博士后、副教授。

1996－1998，美国佐治亚医学院访问学者。

1998至今，清华大学教授。

研究方向

脊椎动物胚胎的分子发育生物学。主要利用斑马鱼做模式动物，分离克隆Nodal和FGF等信号通路的新的介导因子和调节因子，结合分子生物学、细胞生物学、遗传学等技术，研究它们在胚胎发育中的作用及其作用机制。利用诱变技术，鉴定影响早期胚胎发育的母源因子。

获得荣誉

获得何梁何利科技进步奖、谈家桢生命科学成就奖等奖励。现任中国动物学会理事长，中国遗传学会副理士长；先后任National Science Open、National Science Reviews、Development、Journal of Molecular Cell Biology、Open Biology、BMC Developmental Biology、Journal of Cell Science、Current Zoology、Journal of Genetics and Genomics、Cell Research、Mechanisms of Development等杂志编委会或顾问委员会成员。

代表性论文

1、Shen W, Gong B, Xing C, Zhang L, Sun J, Chen Y, Yang C, Yan L, Chen L, Yao L, Li G, Deng H, Wu X, Meng A. * (2022). Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Cell 185, 4954-4970.

2、Jin, H., Han, Y., Wang, H., Li, J.X.H., Shen, W., Zhang, L., Chen, L., Jia, S., Yuan, P., Chen, H., and Meng, A. * (2022). The second polar body contributes to the fate asymmetry in the mouse embryo. Nat Sci Rev, nwac003.

3、Chen, L., Xu, W., Liu, K., Jiang, Z., Han, Y., Jin, H., Zhang, L., Shen, W., Jia, S., Sun, Q., Meng, A.* (2021). 5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos. Sci Adv 7, eabh0494.

4、Zhang, L., Chen, L., Chen, J., Shen, W., and Meng, A.* (2020). Mini-III RNase-based dual-color system for in vivo mRNA tracking. Development 147, dev190728.

5、Jiang, D., Jiang, Z., Lu, D., Wang, X., Liang, H., Zhang, J., Meng, Y., Li, Y., Wu, D., Huang, Y., Chen, Y., Deng, H., Wu, Q., Xiong, J., Meng, A.* and Yu, L.* (2019). Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nat Cell Biol 21, 966-977.

6、Gong, B., Li, Z., Xiao, W., Li, G., Ding, S., Meng, A.* and Jia, S*. (2019). Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis. Nat Commun 10, 1606.

7、Yan, L., Chen, J., Zhu, X., Sun, J., Wu, X., Shen, W., Zhang, W., Tao, Q.*, and Meng, A.* (2018). Maternal Huluwa dictates the embryonic body axis through beta-catenin in vertebrates. Science 362, eaat1045.

8、Zhang, B., Wu, X., Zhang, W., Shen, W., Sun, Q., Liu, K., Zhang, Y., Wang, Q., Li, Y., Meng, A.* and Xie, W.* (2018). Widespread Enhancer Dememorization and Promoter Priming during Parental-to-Zygotic Transition. Mol Cell 72, 673-686 e676.

9、Sun, J., Yan, L., Shen, W., and Meng, A.* (2018). Maternal Ybx1 safeguards zebrafish oocyte maturation and maternal-to-zygotic transition by repressing global translation. Development 145, dev166587.

10、Gao, Q., Zhang, J., Wang, X., Liu, Y., He, R., Liu, X., Wang, F., Feng, J., Yang, D., Wang, Z.*, Meng, A.* and Yan, X.* (2017). The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Nat Commun 8, 15279.

11、Liu, Z., Ning, G., Xu, R., Cao, Y., Meng, A.* and Wang, Q.* (2016). Fscn1 is required for the trafficking of TGF-beta family type I receptors during endoderm formation. Nat Commun 7, 12603.

12、Zhang, J., Jiang, Z., Liu, X. and Meng, A.* (2016). Eph/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development 143, 2603-2615.

13、Xue, Y., Zheng, X., Huang, L., Xu, P., Ma, Y., Min, Z., Tao, Q., Tao, Y.*, and Meng, A*. (2014) Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development. Nat Commun 5, 3766.

14、Xu, P., Zhu, G., Wang, Y., Sun, J., Liu, X., Chen, Y. G., and Meng, A*. (2014) Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos. J Mol Cell Biol 6, 272-285.

15、Liu, X., Xiong, C., Jia, S., Zhang, Y., Chen, Y. G., Wang, Q., and Meng, A*. (2013) Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region. Nat Commun 4, 1728.