基本信息

姓名：张文宏

职称：教授

职务：复旦大学附属华山医院感染科主任、国家感染病临床中心主任

电子邮箱：wenhongzhang@fudan.edu.cn

教育经历

2003.07-2004.07，美国哈佛大学医学院Beth Israel Deaconess医学中心，博士后

1997.07-2001.01，复旦大学，传染病学，博士

1993.09-1996.07，上海医科大学研究生院，中西医结合专业，硕士

1987.09-1993.07，上海医科大学医学系，本科

工作经历

2018.08 –至今，复旦大学，生命科学学院，教授。

2012.10-至今，复旦大学，卫生部重点分子病毒实验室，教授。

2008.05-至今，复旦大学，附属华山医院感染科，教授。

2007.03-2008.04，复旦大学，附属华山医院感染科，主任医师。

2003.07-2004.08，哈佛大学医学院，Beth Israel Deaconess医学中心。

2002.12-2007.03，复旦大学，附属华山医院感染科，副主任医师。

2001.04-2001.10，香港大学，微生物学系，访问学者。

1998.05-2002.11，复旦大学，附属华山医院感染科，主治医师。

1993.09-1998.04，复旦大学，附属华山医院感染科，医师。

研究方向

感染性疾病病原学机制；结核病疫苗；新发突发传染病的病原学和发生发展机制。

获得荣誉

入选教育部新世纪优秀人才、上海市领军人才、上海市优秀学科带头人。获全国创新争先奖，上海市劳动模范，国之名医·优秀风范，上海市医务工匠，上海市银蛇奖。兼中国医师协会内科医师分会副主委，中华预防医学会感染预防与控制分会副主委，中华医学会感染病学分会副主任委员兼秘书长，上海市抗击新冠临床救治专家组长，抗击新冠公共卫生专家组共同组长。兼《中华传染病杂志》总编辑，《微生物与感染》主编，《Emerging Microbes and Infections》副主编，《International Journal of Tuberculosis and Lung Diseases》（国际防痨联盟会刊）副主编。

代表性论文

1、Ai, J., J. Guo, H. Zhang, Y. Zhang, H. Yang, K. Lin, J. Song, Z. Fu, M. Fan, Q. Zhang, H. Wang, Y. Zhao, Z. He, A. Cui, Y. Zhou, J. Wu, M. Zhou, G. Yuan, B. Kang, N. Zhao, Y. Xu, M. Zhu, Y. Wang, Z. Zhang, N. Jiang, C. Qiu, C. Xu and W. Zhang (2022). "Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling." Cell Discov 8(1): 114.

2、Fu, Z. F., H. C. Zhang, Y. Zhang, P. Cui, Y. Zhou, H. Y. Wang, K. Lin, X. Zhou, J. Wu, H. L. Wu, W. H. Zhang and J. W. Ai (2021). "Evaluations of Clinical Utilization of Metagenomic Next-Generation Sequencing in Adults With Fever of Unknown Origin." Front Cell Infect Microbiol 11: 745156.

3、Wang, X., W. Li, W. Wang, S. Wang, T. Xu, J. Chen and W. Zhang (2021). "Involvement of Small Colony Variant-Related Heme Biosynthesis Genes in Staphylococcus aureus Persister Formation in vitro." Front Microbiol 12: 756809.

4、Zhang, W., T. Yang, H. Zhang, Y. Xu, Q. Yang, Q. Liu, Y. Gao, J. Wu, L. Shao and W. Zhang (2021). "Biomarker screening and validation for the differentiation of bloodstream infection from adult-onset Still's disease: A prospective cohort study." Cytokine 146: 155642.

5、Ai, J., X. Wang, X. He, X. Zhao, Y. Zhang, Y. Jiang, M. Li, Y. Cui, Y. Chen, R. Qiao, L. Li, L. Yang, Y. Li, Z. Hu, W. Zhang and P. Wang (2022). "Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2, and BA.3 sub-lineages." Cell Host Microbe 30(8): 1077-1083.e1074.

6、Ai, J., H. Zhang, Q. Zhang, Y. Zhang, K. Lin, Z. Fu, J. Song, Y. Zhao, M. Fan, H. Wang, C. Qiu, Y. Zhou and W. Zhang (2022). "Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern." Cell Res 32(1): 103-106.

7、Ai, J., H. Zhang, Y. Zhang, K. Lin, Y. Zhang, J. Wu, Y. Wan, Y. Huang, J. Song, Z. Fu, H. Wang, J. Guo, N. Jiang, M. Fan, Y. Zhou, Y. Zhao, Q. Zhang, Q. Liu, J. Lv, P. Li, C. Qiu and W. Zhang (2022). "Omicron variant showed lower neutralizing sensitivity than other SARS-CoV-2 variants to immune sera elicited by vaccines after boost." Emerg Microbes Infect 11(1): 337-343.

8、Ai, J., Y. Zhang, H. Zhang, Q. Zhang, Z. Fu, K. Lin, J. Song, Y. Zhao, M. Fan, H. Wang, Y. Zhou, X. Chen, C. Qiu and W. Zhang (2022). "Safety and immunogenicity of a third-dose homologous BBIBP-CorV boosting vaccination: interim results from a prospective open-label study." Emerg Microbes Infect 11(1): 639-647.

9、Jia, L., S. Weng, J. Wu, X. Tian, Y. Zhang, X. Wang, J. Wang, D. Yan, W. Wang, F. Fang, Z. Zhu, C. Qiu, W. Zhang, Y. Xu and Y. Wan (2022). "Preexisting antibodies targeting SARS-CoV-2 S2 cross-react with commensal gut bacteria and impact COVID-19 vaccine induced immunity." Gut Microbes 14(1): 2117503.

10、Jia, L., Y. Zhou, S. Li, Y. Zhang, D. Yan, W. Wang, W. Zhang, Y. Wan and C. Qiu (2022). "Omicron Booster in Ancestral Strain Vaccinated Mice Augments Protective Immunities Against Both Delta and Omicron Variants." Front Immunol 13: 897879.

11、Lin, K., Y. Zhou, J. Ai, Y. A. Wang, S. Zhang, C. Qiu, C. Lian, B. Gao, T. Liu, H. Wang, H. Zhang, Y. Zhang, Z. Fu, D. Li, N. Jiang, J. Guo, J. Wu, Y. O. Wang, S. Song, Q. Li, Y. Yin, J. Xia, Y. Xu, L. S. Yeap, X. Zheng, Y. Gu, H. Liu, W. Zhang and F. L. Meng (2022). "B cell receptor signatures associated with strong and poor SARS-CoV-2 vaccine responses." Emerg Microbes Infect 11(1): 452-464.

12、Lin, S., W. Hua, S. Wang, Y. Zhang, X. Chen, H. Liu, L. Shao, J. Chen and W. Zhang (2022). "In vitro assessment of 17 antimicrobial agents against clinical Mycobacterium avium complex isolates." BMC Microbiol 22(1): 175.

13、Lin, S., W. Zhang, Y. Xu, Q. Liu, W. Zhang and L. Shao (2022). "Gene expression analysis reveals immune and metabolic candidate pathways in the pathogenesis of chronic otitis media." Am J Transl Res 14(1): 264-274.

14、Liu, Q., Y. Gao, T. Yang, Z. Zhou, K. Lin, W. Zhang, T. Li, Y. Lu, L. Shao and W. Zhang (2022). "nCD64 index as a novel inflammatory indicator for the early prediction of prognosis in infectious and non-infectious inflammatory diseases: An observational study of febrile patients." Front Immunol 13: 905060.

15、Ruan, Q. L., Q. L. Yang, F. Sun, W. Liu, Y. J. Shen, J. Wu, N. Jiang, J. Y. Zhou, L. Y. Shao and W. H. Zhang (2022). "Recurrent pulmonary tuberculosis after treatment success: a population-based retrospective study in China." Clin Microbiol Infect 28(5): 684-689.

16、Xu, Y., Q. Yang, J. Zhou, F. Zhou, Y. Hezhang, Y. Gao, L. Shao, J. Shi, Q. Ruan and W. Zhang (2022). "Comparison of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold-Plus in the Diagnosis of Mycobacterium tuberculosis Infections in Immunocompromised Patients: a Real-World Study." Microbiol Spectr 10(2): e0187021.

17、Zhang, H., W. Hua, S. Lin, Y. Zhang, X. Chen, S. Wang, J. Chen and W. Zhang (2022). "In vitro Susceptibility of Nontuberculous Mycobacteria to Tedizolid." Infect Drug Resist 15: 4845-4852.

18、Zhang, Y., J. Ai, J. Bao and W. Zhang (2022). "Lessons learned from the COVID-19 control strategy of the XXXII Tokyo Summer Olympics and the XXIV Beijing Winter Olympics." Emerg Microbes Infect 11(1): 1711-1716.

19、Zhang, Y., C. Chen, J. Wu, J. Jin, T. Xu, Y. Zhou, P. Cui, J. Chen, S. Chen, N. Jiang and W. Zhang (2022). "Sequence-Based Genomic Analysis Reveals Transmission of Antibiotic Resistance and Virulence among Carbapenemase-Producing Klebsiella pneumoniae Strains." mSphere 7(3): e0014322.

20、Zhang, Y., N. Jiang, W. Qi, T. Li, Y. Zhang, J. Wu, H. Zhang, M. Zhou, P. Cui, T. Yu, Z. Fu, Y. Zhou, K. Lin, H. Wang, T. Wei, Z. Zhu, J. Ai, C. Qiu and W. Zhang (2022). "SARS-CoV-2 intra-host single-nucleotide variants associated with disease severity." Virus Evol 8(2): veac106.

21、Zhang, Y., N. Jiang, W. Qi, T. Li, Y. Zhang, H. Zhang, J. Wu, Z. Zhu, J. Ai, C. Qiu and W. Zhang (2022). "Intra-host SARS-CoV-2 single-nucleotide variants emerged during the early stage of COVID-19 pandemic forecast population fixing mutations." J Infect 84(5): 722-746.

22、Zhang, Y., S. Yu, C. Chen, F. Sun, L. Zhou, H. Yao, J. Hu, S. Li, J. Ai, N. Jiang, J. Wang, Q. Liu, J. Jin and W. Zhang (2022). "Comprehensive Surveillance and Sampling Reveal Carbapenem-Resistant Organism Spreading in Tertiary Hospitals in China." Infect Drug Resist 15: 4563-4573.

23、Zhang, Y., Q. Yue, H. Zhu, J. Song, D. Li, W. Liu, S. Jiang, N. Jiang, C. Qiu, J. Ai, Y. Zhang and W. Zhang (2022). "Serum Metabolic Correlates of the Antibody Response in Subjects Receiving the Inactivated COVID-19 Vaccine." Vaccines (Basel) 10(11).

 24、Zhang, Y., H. Zhang and W. Zhang (2022). "SARS-CoV-2 variants, immune escape, and countermeasures." Front Med 16(2): 196-207.

25、Cai, J., K. Lin, H. Zhang, Q. Xue, K. Zhu, G. Yuan, Y. Sun, F. Zhu, J. Ai, S. Wang and W. Zhang (2023). "A one-year follow-up study of systematic impact of long COVID symptoms among patients post SARS-CoV-2 omicron variants infection in Shanghai, China." Emerg Microbes Infect 12(2): 2220578.

26、Chen, X., R. Li, S. Ge, Y. Li, C. Cai, T. Weng, Y. Zhang, J. Jiang, Z. Feng, Y. Chen, Y. Zhang, J. Ma, D. H. Persing, J. Chen, Y. W. Tang, F. Sun and W. Zhang (2023). "Rapid Detection of Extensive Drug Resistance by Xpert MTB/XDR Optimizes Therapeutic Decision-Making in Rifampin-Resistant Tuberculosis Patients." J Clin Microbiol 61(6): e0183222.

27、Li, R., Y. Li, X. Chen, L. Jia, H. Yu, Y. Huang, Q. Wu, M. Xiao, S. Ge, Y. Zhang, Z. Feng, Q. Li, Y. Xu, W. Shi, F. Sun and W. Zhang (2023). "Ability of the MeltPro MTB/PZA Assay to Detect Susceptibility to Pyrazinamide in Rifampin-Resistant Tuberculosis Patients." Microbiol Spectr 11(3): e0483622.

28、Lin, K., H. C. Zhang, Y. Zhang, Y. Zhou, Z. F. Fu, H. Y. Wang, Y. H. Zhao, C. Qiu, M. X. Fan, J. Y. Song, J. W. Ai and W. H. Zhang (2023). "Clinical application and drug-use-guidance value of metagenomic next-generation sequencing in central nervous system infection." Am J Transl Res 15(1): 47-62.

29、Lin, K., Y. Zhao, B. Xu, S. Yu, Z. Fu, Y. Zhang, H. Wang, J. Song, M. Fan, Y. Zhou, J. Ai, C. Qiu, H. Zhang and W. Zhang (2023). "Clinical Diagnostic Performance of Droplet Digital PCR for Suspected Bloodstream Infections." Microbiol Spectr 11(1): e0137822.

30、Ruan, Q. L., Z. C. Wang, C. J. Wei, W. Wang, Q. L. Yang, J. Wu, Y. M. Wan, L. L. Ge, W. H. Zhang and Q. F. Li (2023). "Neutralizing antibodies against SARS-CoV-2 virus after vaccination in patients with neurofibromatosis type 1." Signal Transduct Target Ther 8(1): 233.

31、Wu, Q., H. Wang, J. Cai, J. Ai, Y. Li, H. Zhang, S. Wang, F. Sun, Y. Wu, J. Zhou, Y. Wang, H. Yu and W. Zhang (2023). "Vaccination effects on post-infection outcomes in the Omicron BA.2 outbreak in Shanghai." Emerg Microbes Infect 12(1): e2169197.

32、Zhang, H., M. Zhang, Q. Zhang, Y. Yu, F. Zhang, J. Wang, M. Zhou, T. Yu, C. Shen, S. Yu, Y. Huang, Y. Huang, J. Zhang, J. Jin, C. Qiu, L. Guojun and W. Zhang (2023). "Visualizing in situ viral replication across the natural history of chronic HBV infection." Hepatol Commun 7(4).