基本信息

姓名：杨李

职称：研究员

邮箱：liyang@imu.edu.cn

教育经历

2013/09-2019/06，北京大学，生物学，硕博连读；

2009/09-2013/06，北京大学，生物学，学士。

工作经历

2021/11-2023/12，北京大学医学部基础医学院，博士后；

2019/07-2021/06，北京大学生命科学学院，博士后。

研究方向

哺乳动物肝脏发育及调控机制

获得荣誉

1. 2019-2021年，北京大学博雅博士后基金

2. 2021-2023年，北大-清华生命科学联合中心博士后基金

3. 2021-2023年，国家自然科学基金青年科学基金

代表性论文

1. Li Yang#, Xin Wang#, Jia-Xi Zheng, Zi-Ran Xu, Lin-Chen Li, Yu-Long Xiong, Bi-Chen Zhou, Jie Gao and Cheng-Ran Xu*, Determination of the key events in hepatocyte maturation at the single-cell level. Dev Cell. 31:S1534-5807(23)00348-9 (2023)

2. Li Yang#, Xin Wang#, Xin-Xin Yu, Lu Yang, Jing Yang and Cheng-Ran Xu*, The default and directed pathways of bipotent hepatoblast differentiation involve distinct epigenomic mechanisms. Dev Cell. 18:S1534-5807(23)00332-5 (2023)

3. Lin-Chen Li#, Xin Wang#, Zi-Ran Xu#, Yan-Chun Wang#, Ye Feng, Liu Yang, Wei-Lin Qiu, Li Yang, Xin-Xin Yu, Jun Gu and Cheng-Ran Xu*, Single-cell patterning and axis characterization in the murine and human definitive endoderm. Cell Research, 31(3):326-344 (2021).

4. Sisi Feng#, Jiaying Wu#, Wei-Lin Qiu#, Li Yang#, Xiaogang Deng#, Ying Zhou, Yabin Chen, Xiao Li, Lei Yu, Zi-Ran Xu, Yini Xiao, Xiongzhao Ren, Ludi Zhang, Chenhua Wang, Xiaoyan Ding, Yuelei Chen, Paul Gadue, Guoyu Pan, Mina Ogawa, Shinichiro Ogawa, Jie Na, Lijian Hui, Hao Yin*, Luonan Chen*, Cheng-Ran Xu* and Xin Cheng*, Large-scale generation of functional and transplantable hepatocytes and cholangiocytes from human endoderm stem cells. Cell Reports, 33(10):108455 (2020)

5. Xin Wang#, Li Yang#, Yan-Chun Wang#, Zi-Ran Xu, Ye Feng, Jing Zhang, Yi Wang and Cheng-Ran Xu*, Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level. Cell Research, 30(12):1109-1126 (2020)

6. Ye Feng#, Wei-Lin Qiu#, Xin-Xin Yu, Yu Zhang, Mao-Yang He, Li Yang, Weiyi Zhang, Michael Franti, Junqing Ye*, Joerg D. Hoeck* and Cheng-Ran Xu*, Characterizing pancreatic β-cell heterogeneity in the streptozotocin model by single-cell transcriptomic analysis. Molecular Metabolism, 37:100982 (2020).

7. 杨李，拉毛切忠，徐成冉*，肝脏细胞分化和成熟的分子调控机制。中国细胞生物学学报，41(10):1853-1884 (2019).

8. Li Yang#, Lin-Chen Li#, Lamaoqiezhong, Xin Wang, Wei-Hua Wang, Yan-Chun Wang and Cheng-Ran Xu*, The contributions of mesoderm-derived cells in liver development. Seminars in Cell and Developmental Biology, 92:63-76 (2019).

9. Li Yang#, Wei-Hua Wang#, Wei-Lin Qiu#, Zhen Guo, Erfei Bi and Cheng-Ran Xu*, A single-cell transcriptomic analysis reveals precise pathways and regulatory mechanisms underlying hepatoblast differentiation. Hepatology, 66(5):1387-1401 (2017).

已授权的发明专利

徐成冉，程新，杨李，冯思思，吴佳颖，邱伟林，MAPK/PKC 信号通路激活剂促进人类胆管细胞分化和成熟，CN201710329768.7