基本信息

姓名：乌英嘎

职称：研究员

电子邮箱：wuyingga1991@163.com

教育经历

2013/09-2020/01，中国科学院遗传与发育生物学研究所，发育生物学，硕博连读;

2009/09-2013/07，内蒙古大学，生物学(基地)，学士;

工作经历

2024/05-至今，内蒙古大学生物医学研究院，骏马计划B1岗；

2020/03-2023/09，中国科学院遗传与发育生物学研究所，博士后；

研究方向

课题组主要研究能量代谢调控机制，尤其专注于营养素摄入与肥胖症和糖尿病之间的关系及机体的调控机制。主要以特殊饮食诱导小鼠为研究模型，利用单细胞测序、基因敲除术、光遗传学等技术研究中枢神经系统(下丘脑等)和外周组织信号如何相互作用进一步调控能量平衡的机制，从而为开发治疗肥胖症和糖尿病的药物提供理论基础。

获得荣誉

2021-2023年，全国博士后创新人才支持计划

2021-2023年，博士后科学基金面上资助

代表性论文

1、Wu YG, Li BG, Li L, Mitchell SE, Green CL, D’Agostino G, Wang GL, Wang L, Li M, Li JB, Niu CQ, Jin ZG, Wang AYQ, Zheng Y, Douglas A, Speakman JR. Very low protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice. Cell Metab. 33(5):888-904, (2021).

2、Wu, YG, Green CL, Wang GL, Yang DB, Li L, Li BG, Wang L, Li M, Li JB, Xu YC, Zhang XY, Niu CQ, Hu SM, Togo J, Mazidi M, Derous D, Douglas A, Speakman JR. Effects of dietary macronutrients on the hepatic transcriptome and serum metabolome in mice. Aging Cell. 21(4):e13585, (2022).

3、Wu YG, Hu SM, Yang DB, Li L, Li BG, Wang L, Li M, Wang GL, Li JB, Xu YC, Zhang XY, Niu CQ, Speakman JR. Increased variation in body weight and food intake is related to increased dietary fat but not increased carbohydrate or protein in mice. Front Nutr. 9:835536, (2022).

4、Hu SM^*, Wang L^*, Yang, DB^*, Li L^*, Togo J^*, Wu YG^*, Liu QS, Li BG, Li M, Wang GL, Zhang XY, Niu CQ, Li JB, Xu YC, Couper E, Whittington-Davies A, Mazidi M, Luo LJ, Wang SN, Douglas A, Speakman JR. Dietary fat, but not protein or carbohydrate, regulates energy intake and causes adiposity in mice. Cell Metab. 28(3), 415-431, (2018). (* Co-first author)

5、Li M^*, Li L^*, Li BG^*, Hambly C, Wang G, Wu YG, Jin ZG, Wang A, Niu CQ, Wolfrum C, Speakman JR. Brown adipose tissue is the key depot for glucose clearance in microbiota depleted mice. Nat Commun. 12(1):4725, (2021).

6、Hu SM, Togo J, Wang L,Wu YG, Yang DB, Xu YC, Li L, Li BG, Li M, Li JB, Wang  GL, Zhang XY, Niu CQ, Mazidi M, Douglas A, Speakman JR. Effects of dietary macronutrients and body composition on glucose homeostasis in mice. Natl Sci Rev. 8(1), nwaa177, (2020).

7、Li BG^*, Li L^*, Li M^*, Lam SM^*, Wang GL, Wu YG, Zhang HL, Niu CQ, Zhang XY, Liu X, Hambly C, Jin WZ, Shui GH, Speakman JR. Microbiota depletion impairs thermogenesis of brown adipose tissue and browning of white adipose tissue. Cell Rep. 26(10), 2720-2737, (2019).

已授权的发明专利

约翰.罗杰.斯彼克曼，乌英嘎，一种基于宏亮营养素成分改变和mTOR信号抑制剂的饥饿干预方法和应用，CN202110216587.X